At Illinois

Pending Publications

  • Chen, L.; Chen, A.; Zhang, X. D.; T. Robles, M. S.; Han, H.-S.; Xiao, Y. Xiao, G.; M. Pipas, J.; A. Weitz, D.; “High-sensitivity whole-genome recovery of single viral species in environmental samples”, submitted.
  • Kumar, A.; Schrader, A. W.; Boroojeny, A. E.; Asadian, A.; Lee, J.; Song, Y. J.; Zhao, S. D.*; Han, H.-S.*; Sinha, S.* “Intracellular Spatial Transcriptomic Analysis Toolkit (InSTAnT)”, submitted. article
  • Jankelow, A.; Chen, C.; Cowell, T. W.; Monteros, J. E.; Bian, Z.; Kindratenko, V.; Han H.-S.; Valera, E.; Bashir, R. “Multiplexed Electrical Detection of Whole Viruses from Plasma in a Microfluidic Platform”, submitted.

* Indicates corresponding author(s)

Book Chapters

  • Cowell, T. W.; Han H.-S.*; (2023). “Double Emulsion Flow Cytometry for Rapid Single Genome Detection”. In: Li, P.C., Wu, A.R. (eds) Single-Cell Assays. Methods in Molecular Biology, vol 2689. Humana, New York, NY.  article


  1. Chen, A.; Zhu, L.; Han H.-S.; Arai, Y. “Spectroscopic Investigation of Phosphorus Mineralization as Affected by the Calcite-Water Interfacial Chemistry”, Environ. Sci. Technol. 2023. article
  2. Valera, E.; Kindratenko, V.; Jankelow, A.; Heredia, J.; Cowell, T. W.; Chen, C.-L.; Han, H.-S.; Bashir, R.* “Electrical and Electrochemical Point-of-Care Devices for the Diagnosis of Sepsis”, Curr. Opin. Electrochem, 2023. article
  3. Miller, R. C.; Lee, J.; Kim, Y.; Han, H.-S.*; Kong, H.* “In-drop thermal cycling of microcrystal assembly for senescence control (MASC) with minimal variation in efficacy”, Adv. Funct. Mater, 2023. article
  4. Miller, R.; Kim, Y.; Park, C. G.; Torres, C.; Kim, B.; Lee, J.; Flaherty, D.; Han, H.-S.; Kim, Y. J.*; Kong, H.* “Extending the bioavailability of hydrophilic antioxidants for metal ion detoxification via recrystallization with polysaccharide dopamine”, ACS Appl. Mater. Interfaces, 2022, 14, 35, 39759–39774. article
  5. Martin, J.; Lanning, R.; Chauhan, V.; Martin, M.; Mousa, A.; Kamoun, W.; Han, H.-S.; Lee, H.; Stylianopoulos, T.; Bawendi, M.; Duda, D.; Brown, E.; Padera, T.; Fukumura, D.; Jain, R. “Multiphoton phosphorescence quenching microscopy reveals kinetics of tumor oxygenation during anti-angiogenesis and angiotensin signaling inhibition, Clinical Cancer Research, 2022, 28, 14, 3076-3090. article
  6. Jing, W.; Han, H.-S.* “Droplet Microfluidics for High-Resolution Virology”, Anal. Chem. (invited Perspective), 2022, 94, 23, 8085–8100. article
  1. Cowell, T. W.; Dobria, A.; Han, H.-S.* “Simplified, Shear Induced Generation of Double Emulsions for Robust Compartmentalization during Single Genome Analysis” Biorxiv 2021/469484. ACS Appl. Mater. Interfaces, 2022, 14, 18, 20528–20537. article
  1. Jing, W.; Han, H.-S.* “Inertial Self-Assembly Dynamics of Interacting Droplet Ensembles in Microfluidic Flows” Analytical Chemistry, 2022, 94, 9, 3978-3986. article
  2. Park, J.; Jayaraman, A. R.; Wang, X.; Zhao, J.; Han, H.-S.* “Nanocrystal Precursor Incorporating Separated Reaction Mechanisms for Nucleation and Growth to Unleash the Potential of Heat-up Synthesis” ACS Nano, 2020, 14, 9, 11579-11593. article
  1. Park, J.; Jayaraman, A. R.; Schrader, A. W.;  Hwang, G. W.; Han, H.-S.* “Controllable modulation of precursor reactivity using chemical additives for systematic synthesis of high-quality quantum dots” Nature Comm, 2020, 11, 5748. article (selected as Editor’s highlight, featured article in Materials Science and Chemistry)
  2. Cowell, T. W.; Valera, E.; Jankelow, A.; Park, J.; Schrader, A. W.; Ding, R.; Berger, J; Bashir, R.; Han, H.-S.* “Rapid, Multiplexed Electrical Detection of Biomolecules using Electrically Distinct Hydrogel Beads”, Lab Chip. 2020, 20, 2274-2283. article (selected as the inside front cover article)
Microfluidic Synthesis of Multiplexing Beads


  1. Han H.-S. and Park J. “Precursor chemistry for quantum dot synthesis enabling temperature-independent modulation of reactivity” Provisionally submitted.
  2. Han H.-S., Bashir R., Cowell T. and Valera E. “Electrically distinct hydrogel microparticles for multiplexed detection, quantification and barcoding” U.S.#20200391169. Dec. 17, 2020.

Prior Research


  1. Han H.-S.; Cantalupo P. G.; Rotem A.; Cockrell S. K.; Carbonnaux M.; Pipas J. M.; Weitz D. A. “Whole-Genome Sequencing of a Single Viral Species from a Highly Heterogeneous Sample” Angew. Chem. Int. Ed2015, 54, 13985–13988. article
    * Above article was selected as a “Hot paper”.
  2. Han H.-S.; Niemeyer E.; Huang Y.; Kamoun W. S.; Martin J. D.; Bhaumik J.; Chen Y.; Roberge S.; Cui J.; Martin M. R.; Fukumura D.; Jain R. K.; Bawendi M. G.; Duda D. G. “Quantum Dot/Antibody Conjugates for In vivo Cytometric Imaging in Mice” Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 1350–1355. article
  3. Chen O.; Zhao J; Chauhan V. P.; Cui J.; Wong C.; Harris D. K.; Wei H.; Han H.-S.; Fukumura D.; Jain R. K.; Bawendi M. G. “Compact High-Quality CdSe-CdS Core-Shell Nanocrystals with Narrow Emission Linewidths and Suppressed blinking” Nat. Mater. 2013, 12, 445–451. article
  4. Manfrinato V. R.; Wanger D.D.; Strasfeld D. B.; Han H.-S.; Marsili F.; Arrieta J. P.;Mentzel T. S.; Bawendi M. G.; Berggren K. K. “Controlled Placement of Colloidal Quantum Dots in sub-15-nm Clusters” Nanotechnology. 2013, 24, 125302. article
  5. Han H.-S.; Martin J.; Lee J.; Harris D. K.; Fukumura D.; Jain R. K.; Bawendi M. G. “Spatial Charge Configuration Regulates Nanoparticle Transport and Binding Behavior in vivo” Angew. Chem. Int. Ed. 2013, 52, 1414–1419. article
    * Above article was highlighted in Nat. Mater. 2013, 12, 91.
  6. Wei H.; Insin N.; Lee J.; Han H.-S.; Cordero J. M.; Liu W.; Bawendi M. G. “Compact Zwitterion-Coated Iron Oxide Nanoparticles for Biological Applications” Nano Lett2012, 12, 22–25. article
  7. Harris D. K.; Allen P. M.; Han H.-S.; Walker B. J.; Lee J.; Bawendi M. G. “Synthesis of Cadmium Arsenide Quantum Dots Luminescent in the Infrared”, J. Am. Chem. Soc. 2011, 133, 4676–4679. article
  8. Dorn A.; Strasfeld D. B.; Harris D. K.; Han H.-S.; Bawendi M. G. “Using Nanowires to Extract Excitons from a Nanocrystal Solid” ACS Nano2011, 5, 9028–9033. article
  9. Han H.-S.; Devaraj N. K.; Lee J.; Hilderbrand S. A.; Weissleder R.; Bawendi M. G. “Development of a Bioorthogonal and Highly Efficient Conjugation Method for Quantum Dots using Tetrazine-Norbornene Cycloaddition” J. Am. Chem. Soc. 2010, 132, 7838–7839. article
  10. Verma A.; Uzun O.; Hu Y.; Hu Y.; Han H.-S.; Watson N.; Chen S.; Irvine D. J.; Stellacci F. “Surface-Structure-Regulated Cell-Membrane Penetration by Monolayer-Protected Nanoparticles” Nat. Mater. 2008, 7, 588–598. article


  1. Han H.-S., Pipas, J.M. and Weitz D.A. “Systems and Methods for Sequencing Viruses” Provisionally submitted.
  2. Han H.-S., Wei H., Insin N. and Bawendi M. G. “Compact Nanoparticles for Biological Applications” W.O. Patent #2013090601, Aug. 8, 2013/U.S. #20130184444, July 18, 2013.
  3. Han -S., Devaraj N. K., Hilderbrand S. A., Weissleder R. and Bawendi M. G. “Compositions and Methods for Bioconjugation to Quantum Dots” W.O. Patent #2011112970, Jan. 19, 2012.
  4. Han H.-S., Liu W. and Bawendi M. G.Ligands for Semiconductor Nanocrystals” W.O. Patent #2011119654, Publication date: Sep. 29, 2011/U.S. #20110236315, Sep. 29, 2011