At Illinois

Pending Publications


    • Cowell, T. W.; Jing W.; Han H.-S.*; “Drop-by-drop Addition of Reagents to a Double Emulsion”, submitted. article

    • ‘Kim S. H.; Jo J.; Park T. W.; Chung Y. M.; Song H. H.; Lee S. W.; Park Y.; Moon W. K.; Lee E.J; Hwang G. W.; Jung M. H.; Hong W. K.; Sohn D.; Lee Y.; Yoon K. B.; Shin S. H.; Han H.-S.*; Han Y. K.* “Single-step synthesis of mesoporous vinyl polymers via hierarchical assembly of stereocontrolled chains”, submitted.

    • Cowell, T. W.; Puryear, W.; Chen, C.-L.;  Runstadler, J.; Han, H.-S.* “Unbiased, Cell-free Profiling of Single Influenza Genomes at High-throughput”, submitted. article

    • Chen, L.; Chen, A.; Zhang, X. D.; T. Robles, M. S.; Han, H.-S.; Xiao, Y. Xiao, G.; M. Pipas, J.; A. Weitz, D. “High-sensitivity whole-genome recovery of single viral species in environmental samples”, submitted. article

* Indicates corresponding author(s)

Book Chapters


    • Cowell, T. W.; Han H.-S.* (2023). “Double Emulsion Flow Cytometry for Rapid Single Genome Detection”. In: Li, P.C., Wu, A.R. (eds) Single-Cell Assays. Methods in Molecular Biology, vol 2689. Humana, New York, NY.  article


    1. Park, J.; Han, H.-S.* “Organoborane Se and Te precursors for controlled modulation of reactivity in nanomaterial synthesis”, ACS Nano, accepted.         
    2. Kumar, A.; Schrader, A. W.; Boroojeny, A. E.; Asadian, A.; Lee, J.; Song, Y. J.; Zhao, S. D.*; Han, H.-S.*; Sinha, S.* “Intracellular Spatial Transcriptomic Analysis Toolkit (InSTAnT)”, Nature Communication, accepted. article

    3. Yeo, S.; Schrader, A. W.; Lee, J.; Asadian, A.; Han, H.-S.* “Spot-Based Global Registration for Sub-pixel Stitching of Single-Molecule Resolution Images for Tissue-Scale Spatial Transcriptomics”, Analytical Chemistry, 2024,. 96(17),  6517-6522. article

    1. Lee, J.; Soares, G.; Doty, C.; Park, J.; Hovey, J.; Schrader, A. W.; Han, H.-S.* “Versatile Pre-Polymer Platform for Controlled Tailoring of Quantum Dot Surface Properties”, ACS Appl. Mater. Interfaces, 2024, 16, 12, 15202-15214 .article

    1. Jankelow, A.; Chen, C.; Cowell, T. W.; Monteros, J. E.; Bian, Z.; Kindratenko, V.; Han H.-S.; Valera, E.; Bashir, R. “Multiplexed Electrical Detection of Whole Viruses from Plasma in a Microfluidic Platform”, Analyst, 2024, Advance online publication. article

    1. Chen, A.; Zhu, L.; Han H.-S.; Arai, Y. “Spectroscopic Investigation of Phosphorus Mineralization as Affected by the Calcite-Water Interfacial Chemistry”, Environ. Sci. Technol. 2023, 57(43), 16606–16615. article

    1. Valera, E.; Kindratenko, V.; Jankelow, A.; Heredia, J.; Cowell, T. W.; Chen, C.-L.; Han, H.-S.; Bashir, R.* “Electrochemical Point-of-Care Devices for the Diagnosis of Sepsis”, Curr. Opin. Electrochem, 2023, 39, 101300. article

    1. Miller, R. C.; Lee, J.; Kim, Y.; Han, H.-S.*; Kong, H.* “In-drop thermal cycling of microcrystal assembly for senescence control (MASC) with minimal variation in efficacy”, Adv. Funct. Mater, 2023, 33(37), 2302232. article

    1. Miller, R.; Kim, Y.; Park, C. G.; Torres, C.; Kim, B.; Lee, J.; Flaherty, D.; Han, H.-S.; Kim, Y. J.*; Kong, H.* “Extending the bioavailability of hydrophilic antioxidants for metal ion detoxification via recrystallization with polysaccharide dopamine”, ACS Appl. Mater. Interfaces, 2022, 14, 35, 39759–39774. article

    1. Martin, J.; Lanning, R.; Chauhan, V.; Martin, M.; Mousa, A.; Kamoun, W.; Han, H.-S.; Lee, H.; Stylianopoulos, T.; Bawendi, M.; Duda, D.; Brown, E.; Padera, T.; Fukumura, D.; Jain, R. “Multiphoton phosphorescence quenching microscopy reveals kinetics of tumor oxygenation during anti-angiogenesis and angiotensin signaling inhibition, Clinical Cancer Research, 2022, 28, 14, 3076-3090. article

    1. Jing, W.; Han, H.-S.* “Droplet Microfluidics for High-Resolution Virology”, Anal. Chem. (invited Perspective), 2022, 94, 23, 8085–8100. article


    1. Cowell, T. W.; Dobria, A.; Han, H.-S.* “Simplified, Shear Induced Generation of Double Emulsions for Robust Compartmentalization during Single Genome Analysis” Biorxiv 2021/469484. ACS Appl. Mater. Interfaces, 2022, 14, 18, 20528–20537. article


    1. Jing, W.; Han, H.-S.* “Inertial Self-Assembly Dynamics of Interacting Droplet Ensembles in Microfluidic Flows” Analytical Chemistry, 2022, 94, 9, 3978-3986. article

    1. Park, J.; Jayaraman, A. R.; Wang, X.; Zhao, J.; Han, H.-S.* “Nanocrystal Precursor Incorporating Separated Reaction Mechanisms for Nucleation and Growth to Unleash the Potential of Heat-up Synthesis” ACS Nano, 2020, 14, 9, 11579-11593. article


    1. Park, J.; Jayaraman, A. R.; Schrader, A. W.;  Hwang, G. W.; Han, H.-S.* “Controllable modulation of precursor reactivity using chemical additives for systematic synthesis of high-quality quantum dots” Nature Comm, 2020, 11, 5748. article (selected as Editor’s highlight, featured article in Materials Science and Chemistry)

    1. Cowell, T. W.; Valera, E.; Jankelow, A.; Park, J.; Schrader, A. W.; Ding, R.; Berger, J; Bashir, R.; Han, H.-S.* “Rapid, Multiplexed Electrical Detection of Biomolecules using Electrically Distinct Hydrogel Beads”, Lab Chip. 2020, 20, 2274-2283. article (selected as the inside front cover article)



Microfluidic Synthesis of Multiplexing Beads


Cover art for Lab on a Chip Vol. 20 Issue 13. Multiplexed hydrogel beads are depicted as they are counted and captured on a microfluidic device. This device can rapidly detect and quantify multiple biological targets.



    1. Han H.-S. and Park J. “Precursor chemistry for quantum dot synthesis enabling temperature-independent modulation of reactivity” Provisionally submitted.

    1. Han H.-S., Bashir R., Cowell T. and Valera E. “Electrically distinct hydrogel microparticles for multiplexed detection, quantification and barcoding” U.S.#20200391169. Dec. 17, 2020.

Prior Research



    1. Han H.-S.; Cantalupo P. G.; Rotem A.; Cockrell S. K.; Carbonnaux M.; Pipas J. M.; Weitz D. A. “Whole-Genome Sequencing of a Single Viral Species from a Highly Heterogeneous Sample” Angew. Chem. Int. Ed2015, 54, 13985–13988. article
      * Above article was selected as a “Hot paper”.

    1. Han H.-S.; Niemeyer E.; Huang Y.; Kamoun W. S.; Martin J. D.; Bhaumik J.; Chen Y.; Roberge S.; Cui J.; Martin M. R.; Fukumura D.; Jain R. K.; Bawendi M. G.; Duda D. G. “Quantum Dot/Antibody Conjugates for In vivo Cytometric Imaging in Mice” Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 1350–1355. article

    1. Chen O.; Zhao J; Chauhan V. P.; Cui J.; Wong C.; Harris D. K.; Wei H.; Han H.-S.; Fukumura D.; Jain R. K.; Bawendi M. G. “Compact High-Quality CdSe-CdS Core-Shell Nanocrystals with Narrow Emission Linewidths and Suppressed blinking” Nat. Mater. 2013, 12, 445–451. article

    1. Manfrinato V. R.; Wanger D.D.; Strasfeld D. B.; Han H.-S.; Marsili F.; Arrieta J. P.;Mentzel T. S.; Bawendi M. G.; Berggren K. K. “Controlled Placement of Colloidal Quantum Dots in sub-15-nm Clusters” Nanotechnology. 2013, 24, 125302. article

    1. Han H.-S.; Martin J.; Lee J.; Harris D. K.; Fukumura D.; Jain R. K.; Bawendi M. G. “Spatial Charge Configuration Regulates Nanoparticle Transport and Binding Behavior in vivo” Angew. Chem. Int. Ed. 2013, 52, 1414–1419. article
      * Above article was highlighted in Nat. Mater. 2013, 12, 91.

    1. Wei H.; Insin N.; Lee J.; Han H.-S.; Cordero J. M.; Liu W.; Bawendi M. G. “Compact Zwitterion-Coated Iron Oxide Nanoparticles for Biological Applications” Nano Lett2012, 12, 22–25. article

    1. Harris D. K.; Allen P. M.; Han H.-S.; Walker B. J.; Lee J.; Bawendi M. G. “Synthesis of Cadmium Arsenide Quantum Dots Luminescent in the Infrared”, J. Am. Chem. Soc. 2011, 133, 4676–4679. article

    1. Dorn A.; Strasfeld D. B.; Harris D. K.; Han H.-S.; Bawendi M. G. “Using Nanowires to Extract Excitons from a Nanocrystal Solid” ACS Nano2011, 5, 9028–9033. article

    1. Han H.-S.; Devaraj N. K.; Lee J.; Hilderbrand S. A.; Weissleder R.; Bawendi M. G. “Development of a Bioorthogonal and Highly Efficient Conjugation Method for Quantum Dots using Tetrazine-Norbornene Cycloaddition” J. Am. Chem. Soc. 2010, 132, 7838–7839. article

    1. Verma A.; Uzun O.; Hu Y.; Hu Y.; Han H.-S.; Watson N.; Chen S.; Irvine D. J.; Stellacci F. “Surface-Structure-Regulated Cell-Membrane Penetration by Monolayer-Protected Nanoparticles” Nat. Mater. 2008, 7, 588–598. article



    1. Han H.-S., Pipas, J.M. and Weitz D.A. “Systems and Methods for Sequencing Viruses” Provisionally submitted.

    1. Han H.-S., Wei H., Insin N. and Bawendi M. G. “Compact Nanoparticles for Biological Applications” W.O. Patent #2013090601, Aug. 8, 2013/U.S. #20130184444, July 18, 2013.

    1. Han -S., Devaraj N. K., Hilderbrand S. A., Weissleder R. and Bawendi M. G. “Compositions and Methods for Bioconjugation to Quantum Dots” W.O. Patent #2011112970, Jan. 19, 2012.

    1. Han H.-S., Liu W. and Bawendi M. G.Ligands for Semiconductor Nanocrystals” W.O. Patent #2011119654, Publication date: Sep. 29, 2011/U.S. #20110236315, Sep. 29, 2011